This study aims to test a new eye drop called DFL24498 for people with Dry Eye Disease (DED). DED makes your eyes feel dry, itchy, or burning. The study will compare the effects of DFL24498 to a placebo (a pretend treatment) to see if it helps. It will last up to 16 weeks with three study periods. About 417 adults will take part in the U.S.

To join, you must have had DED for at least 6 months and meet certain test conditions like the Schirmer I test, which measures tear production. You also must have good enough vision according to a special vision chart. However, if you have an active eye infection, need eye surgery soon, or have had eye surgery recently, you cannot participate.

• The study involves regular eye check-ups and tests over 16 weeks.
• You must be 18 or older and speak the local language to understand study details.
• Participants will compare the new eye drop to a placebo to check its effectiveness.