This study looks at how two new medicines, botensilimab and balstilimab, work in people with advanced colorectal cancer that can be surgically removed. *Colorectal cancer* is a type of cancer that affects the colon or rectum. Sometimes, this cancer can spread to other parts of the body. In this study, the medicines are given before surgery to help the immune system attack the cancer and make the tumor smaller. This approach is called *neoadjuvant therapy*.

Both medications are types of *immunotherapy*, which means they help your body's defenses fight the cancer. The study will also look at how safe these medicines are and if they improve the chances of the cancer not coming back.

• The study involves getting medicine through a vein over several weeks and then having surgery.
• Participants will have follow-up visits for up to three years after treatment.
• Eligibility requires being 18 or older and having certain types of colorectal cancer.

If you join this study, you will have regular check-ups and scans to see how the treatment is working. The goal is to find better ways to treat colorectal cancer and help people live longer and healthier lives.