Image

The ADVANCE (Assay Development and Validation for Pre-Natal and Obstetric Conditions) Study is the Largest U.S.-Based Prospective Study Demonstrating a Circulating Fetal Cell (CFC) Based Approach to Non-invasive Fetal Risk Assessment

ADVANCE Study explores non-invasive way to assess fetal risk.

Recruiting
Female
Phase N/A

The ADVANCE Study is looking at a new way to check a developing baby's health using a test called circulating fetal cell (CFC) assay. This test is special because it uses cells from the baby's placenta found in the mother's blood, so there's no need for risky procedures. These fetal cells are mainly found in the early part of pregnancy. Researchers have created a test, called UNITY Confirm, that looks at these cells to check the baby's chromosomes, which are important for its development.

This study involves pregnant people between 10 and 20 weeks along with one baby. It plans to include more than 1,000 participants and compares the results of CFC testing with other tests done before or after the baby is born. If you are pregnant and healthy, you might be able to join.

  • Who can join? Pregnant individuals 10-20 weeks with one baby.
  • What it involves: Blood test to check baby's health.
  • Who can't join? Those with active cancer.
Study details
    Pregnant Individuals
    Aneuploidy
    Down Syndrome (Trisomy 21)
    22q11.2 Deletion Syndrome
    Trisomy 13
    Trisomy 18
    Sex Chromosome Abnormalities

NCT07643896

BillionToOne Inc.

13 June 2026

Step 1 Get in touch with the nearest study center
We have submitted the contact information you provided to the research team at {{SITE_NAME}}. A copy of the message has been sent to your email for your records.
Would you like to be notified about other trials? Sign up for Patient Notification Services.
Sign up

Send a message

Enter your contact details to connect with study team


Email

View email

Phone

Phone country flag

View phone
Investigator Avatar

Primary Contact

  Other languages supported:

First name*
Last name*
Email*
Phone number*
Race
Ethnicity
Other language

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.