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A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)

Join a study for advanced ovarian cancer treatment research.

Recruiting
18 years and older
Female
Phase 3

This study is for people with advanced ovarian cancer, a type of cancer that affects the ovaries. The study is testing a new medicine called *sacituzumab tirumotecan* (sac-TMT), which is a targeted therapy. This means it works by focusing on specific cancer cells to stop them from growing and spreading. Researchers want to know if sac-TMT helps patients live longer without their cancer getting worse, compared to the standard treatments people usually receive.

Standard care after surgery and chemotherapy often includes maintenance treatment or observation. Maintenance treatment uses medicines like bevacizumab to keep cancer from coming back.

  • Participants will receive sac-TMT either with or without bevacizumab.
  • Eligibility includes having completed certain surgeries and chemotherapy, and having well-controlled health conditions like HIV.
  • Participants must not have other serious health issues or additional active cancers.

This study could offer new hope for patients with this type of cancer by potentially improving their outcomes with new treatment options.

Study details
    Ovarian Neoplasms
    Ovarian Cancer

NCT07318558

Merck Sharp & Dohme LLC

18 July 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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