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Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)

Switching to Maridebart Cafraglutide for weight management in adults.

Recruiting
18-99 years
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

The study is about testing a new medication called maridebart cafraglutide for people with obesity or who are overweight. These people have already been using a type of treatment called GLP-1RA (which helps in losing weight) and have lost at least 10% of their body weight. The study aims to find out if switching to maridebart cafraglutide is safe and effective.

  • The study is only for adults with a Body Mass Index (BMI) of 25 or more.
  • People should have a stable body weight and treatment dose before joining.
  • Women must use contraception and all participants should be willing to follow study rules.

People cannot join if they have other health issues causing obesity, like Cushing's syndrome, or if they have diabetes, certain cancers, or a history related to thyroid cancer. The study is not for those who have been part of a maridebart cafraglutide trial before. If you meet these requirements and are interested, consider the commitment and potential risks involved before participating.

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Study details
    Obesity or Overweight

NCT07575399

Amgen

13 June 2026

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