This study is investigating how different flavors in electronic cigarettes (ENDS) can help smokers quit their usual brand of cigarettes. Participants are given ENDS with various flavors like tobacco, menthol, mint, or others for three months. The study is being conducted at multiple locations and involves healthy adult smokers aged 21-65.

Participants will first take a questionnaire to see if they qualify. If eligible, they will attend a screening and enrollment visit. The study lasts 13 weeks, including a 1-week trial period to try the flavors. Participants will visit the study site on days 0, 30, 60, and 90 and can choose different flavors within their group. They'll also complete surveys through a mobile app about their smoking habits and flavor preferences.

Key Points:

• Study lasts 13 weeks with multiple visits required.
• Participants will use ENDS with different flavors.
• Surveys and safety monitoring are part of the study.