This clinical trial is for people with advanced prostate cancer. Prostate cancer is a disease where cells in the prostate gland grow uncontrollably. The study involves testing a combination of drugs: JNJ-87189401, JNJ-78278343, and possibly others, to find the best treatment approach. Some parts of the study test combinations with a medicine called apalutamide, which blocks male hormones that fuel cancer, or with lutetium Lu-177 vipivotide tetraxetan, a radioactive drug that targets cancer cells.
Key Points:
- The study requires multiple visits and tests to monitor safety and effectiveness.
- Participants may receive different drug combinations based on the study phase.
- Potential risks include side effects from the medications or the procedures involved.
To join, participants need a confirmed diagnosis of prostate cancer and must continue hormone therapy if they've had prior treatment. Those with recent heart issues or autoimmune diseases cannot participate. The study aims to discover safe and effective treatments for advanced prostate cancer.