This study looks at how a medicine called nipocalimab helps adults with moderate to severe Systemic Lupus Erythematosus (SLE). SLE is a condition where the body's defense system attacks healthy parts by mistake, causing swelling and redness in organs. This study compares nipocalimab with a placebo, which is a sugar pill that doesn't contain real medicine.

• The study is for adults who have been diagnosed with SLE for at least 24 weeks.
• Participants need to be medically stable and fit certain health criteria, like having a specific SLE activity score.
• The study checks for allergies to nipocalimab or the placebo ingredients.

To join, participants must be stable health-wise and have a negative pregnancy test if they can have children. They should not have severe, uncontrolled diseases or allergies. The study helps researchers understand how effective nipocalimab is in treating SLE. If you have questions, it's best to talk to your doctor before joining.