This study is testing a new medicine called AMG 513 to see if it is safe for people with obesity. The study will have two parts: Part A and Part B. People who join must be between the ages of 18 and 65, and have a body mass index (BMI) between 30.0 and 40.0 for Part A, or between 27.0 and 40.0 for Part B. BMI is a number calculated from a person's weight and height that shows if they are overweight. Women in the study must not be able to have children.

Some people cannot join this study. For example, anyone with diabetes or very high triglycerides (a kind of fat found in blood) cannot participate. The researchers will check your health to make sure you meet these requirements.

• The study involves taking multiple doses of the medicine.
• Participants must visit the study site multiple times for health check-ups.
• The focus is on safety, so your health will be closely monitored.