This study aims to compare the safety and effectiveness of vapendavir, a medicine taken by mouth, for treating RV (rhinovirus) in people with COPD (Chronic Obstructive Pulmonary Disease). COPD is a lung disease that makes it hard to breathe, causing symptoms like coughing and shortness of breath. Participants will help researchers find the best dose of vapendavir to reduce symptoms. A placebo, which is a harmless pill with no medicine, will also be used for comparison.

To join, you need to be between 40-85 years old, already diagnosed with COPD, and have experienced COPD flare-ups. You should be able to use a mobile app, do nasal swabs at home, and interact with people regularly without a mask. You will need to use effective birth control during the study if you are of child-bearing age. If you're currently taking COPD medicine, it should be stable for at least 2 months.

• Study requires use of a mobile app for daily updates.
• Participants must be able to interact socially at least twice a week.
• Stable medication use is necessary before joining the study.