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This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

We're testing if Mevrometostat plus Enzalutamide is more effective for mCSPC.

Recruiting
18 years and older
Male
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is testing a new drug, *mevrometostat*, combined with another drug, *enzalutamide*, for men with a type of prostate cancer called **mCSPC** (metastatic Castration-Sensitive Prostate Cancer). The study will compare this combination to enzalutamide alone to see which works better. Participants must not have had other cancer treatments except for a type of therapy called *androgen-deprivation therapy* (ADT) for up to 3 months. The study involves several phases: screening, randomization (1:1 chance of receiving the new treatment or a placebo), treatment, safety follow-up, and long-term follow-up.

Who can join: Men aged 18 or older with a specific type of prostate cancer and not having received certain other cancer treatments. They must also be in good health otherwise.

  • Study length includes screening, treatment, and follow-up phases.
  • Participants may receive a combination of drugs or a placebo with enzalutamide.
  • Participants should be aware of risks and the need to follow study guidelines strictly.
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Study details
    Metastatic Castration Sensitive Prostate Cancer (mCSPC)
    Hormone Sensitive Prostate Cancer
    Prostate Cancer
    Cancer of the Prostate

NCT07028853

Pfizer

4 July 2026

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