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Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 mg) Intravitreal Implants vs Observation for Prevention of VA Loss Due to Radiation Retinopathy

Comparing eye injections and implants to observation for radiation retinopathy.

Recruiting
18 years and older
All
Phase 3
This study looks at how two treatments, **faricimab injections** and **fluocinolone acetonide (FAc) implants**, help prevent vision loss compared to just watching patients after treating **choroidal melanoma**. Choroidal melanoma is a type of eye cancer. The treatments are given directly into the eye, a process called **intravitreal injection**. The study wants to find out if these treatments help keep vision longer after a type of radiation therapy called **iodine-125 plaque brachytherapy**. This therapy is used to treat the eye cancer. The study will also check if these treatments can stop or change **macular edema (ME)**, which is swelling in a part of the eye, caused by radiation. **Visual acuity (VA)** is how well you can see, like reading letters on an eye chart. **Key Points:** 1. Participants need to have had iodine-125 plaque brachytherapy for choroidal melanoma. 2. Study involves regular eye check-ups with imaging tests like photos and scans. 3. Eligibility includes being at least 18 years old with certain vision levels and no other eye problems. This study does not mention compensation or risks directly.
Study details
    Radiation Retinopathy
    Visual Impairment

NCT05844982

Jaeb Center for Health Research

6 June 2026

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