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AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

Join AMAZE 4 Study: Explore weight loss and sleep apnea improvements.

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)
Study Summary This study examines how well a new medicine called NNC0487-0111 helps people with extra weight and a sleep condition called obstructive sleep apnoea (OSA) improve their health. OSA is when breathing stops and starts during sleep. The treatment is given as a shot under the skin once a week. Participants will either receive the new medicine or a placebo, which is like a fake medicine with no active ingredients. The selection is random, like flipping a coin. Key Points:
  • The study involves weekly injections and participants may receive either the tested medicine or a placebo.
  • To join, you must be 18 or older and have been diagnosed with moderate-to-severe OSA, but not have diabetes or recent surgeries.
  • The study aims to find out if the medicine is safe and effective for weight loss and improving sleep apnoea.
Before participating, consider if you meet the criteria and are comfortable with regular injections.
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Study details
    Obesity
    Overweight
    Obstructive Sleep Apnoea

NCT07571109

Novo Nordisk A/S

6 June 2026

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