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Testing Whether High Dose Chemotherapy and Infusion of the Patients' Own Stem Cells Improves Survival in Patients With Peripheral T-cell Lymphoma Who Achieved a Complete Response at the End of the Initial Chemotherapy

Testing if high-dose chemo with stem cells boosts survival in T-cell lymphoma.

Recruiting
18-75 years
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is looking at ways to improve survival for people with a type of blood cancer called Peripheral T-cell Lymphoma (PTCL). The study compares two groups: one group will just be watched carefully, while the other group will get high dose chemotherapy followed by an autologous stem cell transplant (ASCT), which means using their own stem cells to help recover from the strong chemotherapy. In this process, stem cells are collected from the patient before chemotherapy and then put back into their body after the chemotherapy is done. This helps the bone marrow, where blood cells are made, to recover.

  • Participants will be followed for a total of 12 years, with frequent check-ups in the first few years.
  • Eligibility includes being 18-75 years old and having specific health criteria met.
  • This study may involve risks associated with high dose chemotherapy and stem cell transplant.
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Study details
    Anaplastic Large Cell Lymphoma
    ALK-Negative
    Follicular Helper T-Cell Lymphoma
    Follicular Helper T-Cell Lymphoma
    Angioimmunoblastic-Type
    Peripheral T-Cell Lymphoma
    Not Otherwise Specified

NCT06724237

Eastern Cooperative Oncology Group

20 June 2026

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