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Ivosidenib as Post-HSCT Maintenance for AML

Ivosidenib may help maintain AML remission after stem cell transplant.

Recruiting
18-75 years
All
Phase 2

This study is about testing a drug called **ivosidenib** for patients with a specific type of blood cancer called **acute myeloid leukemia (AML)**. This drug targets a mutation in a gene called **IDH1**. After a special treatment called **hematopoietic stem cell transplantation (HCT)**, the study wants to see if ivosidenib can stop the cancer from coming back. The study is in **Phase 2**, which means it's testing the drug's effectiveness and safety.

The study will last about **3.5 years** and includes up to **24 months of treatment**. After treatment, there will be a follow-up for **12 more months**. Around **75 people** will join this study. Participants will get either ivosidenib or a **placebo**, which looks like the drug but doesn't have active ingredients. They won’t know which one they’re receiving.

  • Participation involves regular evaluations and follow-ups.
  • It is important to have stable health conditions to join.
  • Pregnant women or those planning pregnancy need to use effective birth control.
Study details
    IDH1 Mutation
    Acute Myeloid Leukemia (AML)
    Hematopoietic Stem Cell Transplant (HSCT)

NCT06707493

Massachusetts General Hospital

30 May 2026

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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