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ALTO-207 in Adults With Treatment-resistant Depression (TRD)

Participate in a study for treatment-resistant depression.

Recruiting
18-75 years
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is for adults aged 18-75 with Treatment-resistant Depression (TRD). This is when a person has Major Depressive Disorder (MDD) but doesn’t get better after trying at least 2-5 antidepressant treatments. The study will test how well a new drug, ALTO-207, works compared to a placebo (a "sugar pill" with no medicine). Participants must already be taking 1-2 antidepressants and can't have unstable medical conditions or severe mental health issues like bipolar disorder or PTSD (Post-Traumatic Stress Disorder). If you have allergies to ALTO-207, or are using certain other medications, you can't join.

  • Study involves comparing ALTO-207 with a placebo for TRD patients.
  • Participants need to be on stable doses of antidepressants.
  • Can't join if you've been in a recent mental health trial with test products.
Consider joining if you meet the requirements, but remember, discussing with your doctor is important to decide what's best for your health.
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Study details
    Treatment-resistant Depression (TRD)

NCT07553637

Alto Neuroscience

2 May 2026

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