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BMS-986489 (Atigotatug + Nivolumab) vs Durvalumab in Limited-stage Small-cell Lung Cancer (TIGOS-LS)

Comparing treatments for limited-stage small-cell lung cancer in a clinical study.

Recruiting
18 years and older
All
Phase 2

This study is checking two treatments for a type of lung cancer called limited-stage small-cell lung cancer (LS-SCLC). One treatment involves two drugs, BMS-986489, which combines atigotatug and nivolumab, and the other is a drug called durvalumab. These drugs are used after chemotherapy and radiotherapy to try and stop the cancer from coming back. Atigotatug is a special type of medicine that helps the immune system target cancer, and nivolumab helps the immune system fight cancer cells. Durvalumab also helps the immune system.

  • Participants must be at least 18 years old and have completed chemotherapy and radiotherapy.
  • Potential side effects and safety of the treatments will be closely monitored.
  • The study will involve random assignment to one of the two treatment groups.

Participants will need to follow certain medical guidelines and maintain regular follow-ups throughout the study. Before joining, it's important to understand the possible risks and benefits and discuss with a healthcare provider.

Study details
    Limited Stage Small Cell Lung Cancer

NCT06773910

SCRI Development Innovations, LLC

11 July 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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