This study looks at whether using *MDMA (a psychoactive drug)* along with Massed Prolonged Exposure (PE) therapy can help treat **PTSD (Posttraumatic Stress Disorder)** better than PE therapy alone. PTSD is a condition some people get after experiencing a scary event. It's like a constant feeling of fear that doesn't go away. In this study, 95 adults with PTSD will either receive MDMA or a placebo (a sugar pill) during one of their 10 therapy sessions. These sessions happen over two weeks. Researchers will check on participants one month after the treatment to see if their PTSD symptoms have improved. They will also see if MDMA helps the brain respond to fear differently. The study aims to find better ways to treat PTSD.
- Participants will attend 10 therapy sessions over two weeks.
- They will receive MDMA or a placebo in the second session.
- Participants will have a follow-up assessment one month after treatment.
Participants need to be able to swallow pills, communicate in English, and meet specific health criteria. There are some risks, like increased heart rate, so medical conditions will be closely reviewed before participation.