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Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-line Treatment in Stage IIIB-IV Non-small Cell Lung Cancer, IMMUNO-BIOMAP Trial

Study on predicting lung cancer treatment response with biomarkers.

Recruiting
18 years and older
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study looks at treating non-small cell lung cancer (NSCLC) at advanced stages. NSCLC is a type of lung cancer that doesn't grow as quickly as small cell lung cancer. The trial aims to understand how well a group of medications called immunotherapy works. Immunotherapy helps the body's immune system fight cancer. Doctors will study biomarkers—substances in your body that can signal how well a treatment might work. They will also check circulating tumor DNA (ctDNA), which is pieces of tumor DNA found in the blood, to see if it helps predict treatment success. The trial involves taking blood and other bodily fluid samples and possibly tumor tissue.

  • The study can last up to 24 months with regular doctor visits.
  • Participants who respond to the first treatment may continue or change their medicine.
  • You may need to stop treatment if side effects are too strong.

Consider joining if: You have advanced NSCLC, and your doctor thinks immunotherapy might help. You should be willing to undergo regular tests and follow the study plan closely.

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Study details
    Lung Non-Small Cell Carcinoma
    Stage IIIB Lung Cancer AJCC v8
    Stage IV Lung Cancer AJCC v8

NCT07288034

City of Hope Medical Center

25 April 2026

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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