This study is exploring if a special method called the **PAGODA algorithm** can help with chemotherapy for **gastrointestinal (GI) cancer**. Chemotherapy is a treatment that uses strong medicines to kill cancer cells. The PAGODA algorithm is a guide to help decide if the dose of chemotherapy should be changed to avoid unplanned delays in treatment. This study will compare two groups: one using the usual care method and the other using the PAGODA algorithm.

**FOLFOX** is a common chemotherapy regimen for GI cancer involving a combination of three drugs: 5-FU, oxaliplatin, and leucovorin. The study aims to see if using the PAGODA algorithm reduces treatment delays and other side effects like neutropenia, a condition where white blood cell count drops, making infections more likely.

• The study will last for several chemotherapy cycles, each 14 days long.
• Participants must be 18 years or older, with certain health criteria met.
• The study is interventional, meaning it involves active treatment changes.