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Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) Therapy

Testing Maridebart Cafraglutide vs. placebo for sleep apnea without PAP therapy.

Recruiting
18-99 years
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study tests a new medicine called maridebart cafraglutide for people with obstructive sleep apnea (OSA) who don't use positive airway pressure (PAP) therapy. OSA is when breathing stops and starts during sleep. The study lasts for 52 weeks to check how well the medicine works and its safety compared to a placebo, which is a pill with no active medicine.

Participants should have an Apnea-Hypopnea Index (AHI) of 15 or more, meaning they have moderate to severe sleep apnea. They must have a Body Mass Index (BMI) of 27 or higher, which means they are overweight or obese, and have tried to lose weight without success. Participants should not have used PAP for at least 4 weeks before the study and must agree not to use it during the study.

Key Points:

  • The study lasts for one year with several visits to the study site.
  • Participants will receive either the study drug or a placebo.
  • Those involved should not be using any other OSA treatments during the study.
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Study details
    Obstructive Sleep Apnea

NCT07226765

Amgen

18 April 2026

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