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Open-Label Study of Pocenbrodib Alone and in Combination With Abiraterone Acetate, Olaparib, or 177Lu-PSMA-617

Study of Pocenbrodib alone or with other medications for treatment.

Recruiting
18 years and older
Male
Phase 1/2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is investigating if a new drug called Pocenbrodib can help treat advanced prostate cancer. Some patients will get Pocenbrodib alone, while others will receive it with other medicines like Abiraterone acetate, Olaparib, or 177Lu-PSMA-617. Advanced prostate cancer means it has spread (metastasized) and doesn't respond to hormone treatment (castration-resistant).

In the first part of the study, different doses of Pocenbrodib will be given to find a safe amount. If it’s safe and works well, the study moves on to see how Pocenbrodib works on its own and with other treatments.

  • Study Length: The study has different phases; each phase has separate criteria and goals.
  • Visits Needed: Participants will need to visit the study center regularly for treatment and check-ups.
  • Eligibility: Participants must be 18 or older with specific types of prostate cancer.

If you join, you might help in finding new treatments for prostate cancer. However, there are some risks and requirements, so discuss with your doctor before deciding.

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Study details
    mCRPC (Metastatic Castration-resistant Prostate Cancer)
    Genital Neoplasms
    Male
    Urogenital Neoplasms
    Urogenital Cancers
    Prostatic Diseases
    Prostatic Neoplasms
    Male Urogenital Diseases
    Neoplasms
    Neoplasms by Site
    Prostate Cancer

NCT06785636

Pathos AI, Inc.

18 April 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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