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A Study of Suvorexant (MK-4305) for the Treatment of Insomnia Disorder in Participants With Opioid Use Disorder (MK-4305-098)

Testing Suvorexant for insomnia in people with opioid use disorder.

Recruiting
18-70 years
All
Phase 3

This study is for people with *Opioid Use Disorder (OUD)*, who have trouble sleeping. The researchers aim to see if a medicine called **suvorexant** can help them sleep better. Suvorexant is a medication commonly used to treat insomnia, which is when someone finds it hard to fall asleep or stay asleep. The study will compare suvorexant to a **placebo**. A placebo is a fake treatment that looks like the real medicine but doesn't contain any active ingredients.

**Key Points to Consider:**

  • The study requires participants to have a regular bedtime between 8 PM and 1 AM and maintain it throughout the study.
  • Participants must not have used opioids for at least 4 weeks prior to the study.
  • Exclusion criteria include having certain mental health disorders or a history of serious sleep disorders.

If you have OUD, are on stable medication, and struggle with insomnia while meeting the criteria, this study might be an opportunity to try a new treatment for better sleep.

Study details
    Insomnia

NCT06655883

Merck Sharp & Dohme LLC

19 September 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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