This study checks if a new medicine, NNC0487-0111, is safe and helps people lose weight. Participants will receive injections under their skin once a week. Some will get the new medicine, while others will get a Placebo (a dummy treatment with no real medicine). The choice of treatment is random, like flipping a coin.

Key Points:

• The study involves weekly injections.
• Participants are randomly assigned to receive either the real medicine or a placebo.
• Participants should have tried losing weight before without success.

To join, you need to be an adult who has attempted to lose weight but hasn't been successful. You can't join if you have diabetes, a high blood sugar level (HbA1c ≥ 6.5%), or have used specific diabetes medicines before. Before joining, you must agree to participate by signing a consent form. This study helps doctors understand if NNC0487-0111 can be a new way to support weight loss safely.