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Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

Testing new treatment for young patients with resistant or returning leukemia.

Recruiting
1-30 years
All
Phase 1
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is testing a new drug revumenib in combination with other drugs to treat a type of blood cancer called Acute Myeloid Leukemia (AML) or Acute Leukemia of Ambiguous Lineage (ALAL), which either didn’t improve with usual treatment (refractory) or came back (relapsed). The goal is to see if this combination is safe and effective.

Participants will take revumenib along with two other drugs, azacitidine and venetoclax. The dose of revumenib might be adjusted based on side effects. The study will check if this new combination can help patients achieve complete remission, which means no signs of cancer.

  • Participation Length: The study involves different dose levels; time on treatment may vary.
  • Eligibility: Participants aged 1-30 with specific cancer conditions, good organ function, and not pregnant can join.
  • Risks: Possible side effects from the drugs, but adjustments will be made for safety.
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Study details
    Refractory Acute Myeloid Leukemia
    Relapsed Acute Myeloid Leukemia
    Acute Leukemia of Ambiguous Lineage

NCT06177067

St. Jude Children's Research Hospital

4 April 2026

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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