Image

A Study of a Thyroid Hormone Receptor Beta Isoform (THRβ) Agonist and an Semicarbazide Sensitive Amine Oxidase (SSAO) Inhibitor, Alone and in Combination, in Adults With Presumed Metabolic Dysfunction-associated Steatohepatitis (MASH)

Exploring new treatments for liver health in adults with MASH.

Recruiting
18 years and older
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study looks at two drugs, ECC4703 and ECC0509, for people with MASH, a liver disease. MASH stands for Metabolic Dysfunction-associated Steatohepatitis. One drug is a *Thyroid Hormone Receptor Beta Isoform (THRβ) agonist*, which helps regulate metabolism. The other is a **Semicarbazide Sensitive Amine Oxidase (SSAO) inhibitor**, which affects fat in the liver. This study measures how these drugs, alone and together, reduce liver fat over 12 weeks using MRI scans.

  • Participants must be 18 or older and have MASH with specific liver and health criteria.
  • The study lasts for 12 weeks, and participants will have MRI scans to track liver fat changes.
  • People with other liver diseases, uncontrolled diabetes, or significant recent health issues can't join.

If you join, you'll need to follow study procedures, including taking the medication and attending visits. The study aims to find the best dose for reducing liver fat. As with any clinical trial, there are risks, and it's important to consider your health and the study requirements before participating.

Print
Study details
    Metabolic Dysfunction-associated Steatohepatitis

NCT07288138

Eccogene

21 March 2026

Contact a study center
Step 1 Get in touch with the nearest study center
We have submitted the contact information you provided to the research team at {{SITE_NAME}}. A copy of the message has been sent to your email for your records.
Would you like to be notified about other trials? Sign up for Patient Notification Services.
Sign up

Send a message

Enter your contact details to connect with study team

Investigator Avatar

Primary Contact

  Other languages supported:

First name*
Last name*
Email*
Phone number*
Race
Ethnicity
Other language

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.