This study is testing a new drug, AVZO-1418, to see if it's safe and can help treat certain cancers. The study is split into two parts, or phases. Phase 1 will find out the safest dose of AVZO-1418 to give patients, while Phase 2 will see how well the drug works alone or with other treatments. The drug is given intravenously, meaning it's put directly into your vein.

To join, you must be 18-75 years old and have a type of cancer known as locally advanced or metastatic epithelial solid tumors. This means the cancer has spread beyond its original spot. You can't join if you have uncontrolled high blood pressure, certain heart or lung problems, or recent infections needing strong medicine.

• The study involves receiving the drug through your vein.
• The study is for adults with specific types of cancer.
• You must be willing to share medical test results to confirm eligibility.