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Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapy

Study compares AAA817 with standard care for mCRPC after Lu-PSMA therapy.

Recruiting
18 years and older
Male
Phase 2/3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is for adults with a specific type of advanced prostate cancer called PSMA-positive mCRPC (metastatic castration-resistant prostate cancer). These patients have already tried certain treatments, like androgen receptor pathway inhibitors (ARPI) and taxane-based chemotherapy, and their disease has progressed after a treatment called [177Lu]Lu-PSMA targeted therapy. The study aims to compare a new treatment, AAA817, to the usual treatments chosen by doctors.

The study is divided into two phases: a Phase II to gather more information about the dose of AAA817, and a Phase III to test how well AAA817 works compared to standard treatments. Participants must be 18 or older, have confirmed prostate cancer, and meet other health criteria.

  • The study includes two parts: Phase II and Phase III, focusing on dose and effectiveness.
  • Participants must have tried specific prior treatments and have progressed after them.
  • People with certain health conditions or recent other treatments may not be eligible.
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Study details
    Prostate Cancer

NCT06780670

Novartis Pharmaceuticals

11 April 2026

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