**Efficacy and Safety of KAI-9531 for Weight Loss** This study checks how well a new medicine called KAI-9531 helps people lose weight safely. The medicine is given as a shot under the skin every week. It compares KAI-9531 to a placebo, which is a pretend medicine that doesn’t do anything. People who can join have a BMI (Body Mass Index) of 30 or higher, or 27 with other health issues like high blood pressure or heart problems, but not diabetes. They also need a history of trying to lose weight without success. **Key points:** 1. **Weekly Visits:** You will need to visit the study center once a week for a shot. 2. **Eligibility:** Check if your medical history matches the study rules, especially if you take certain medicines or have some health issues. 3. **No Diabetes:** This study is only for people without diabetes. **Note:** Always talk with your doctor before joining a study. This summary does not cover all criteria or potential risks.