This study is testing a new drug called GSK4532990 for adults aged 18 to 65 with alcohol-related liver disease. The drug's safety (how safe it is for people) and efficacy (how well it works) are being checked. People with this liver disease usually have liver damage from drinking too much alcohol. A *placebo* is a fake treatment that looks like the real drug but doesn't have any active ingredients; it's used to compare results.

Key Points:

• The study involves taking either the new drug or a placebo.
• Participants need to meet certain health conditions and attend regular check-ups.
• There may be risks, like side effects or health changes.

Participants must be able to give consent, follow the study rules, and have a history of alcohol use that fits the study's criteria. Certain health conditions or past medical procedures, like organ transplants or severe cardiovascular events, can disqualify a participant. The study ensures safety by excluding people with very high liver enzymes or other severe health issues.