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A Study of JNJ-90301900 in Combination With Chemoradiation Therapy in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma

Exploring JNJ-90301900 with chemoradiation for advanced head and neck cancer.

Recruiting
18-74 years
All
Phase 1
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is testing a new treatment called JNJ-90301900 for a type of cancer that starts in the outer layers of the mouth and throat, known as Head and Neck Squamous Cell Carcinoma (HNSCC). The study aims to see if this treatment is safe and effective when used with standard cancer treatments like chemotherapy and radiation. The treatment is injected directly into the tumor. The study is in Phase 1b, which means it is in the early stages of testing.

  • The study requires participants to have a specific stage of HNSCC (Stage III, IVA, or IVB).
  • Participants will undergo treatment with JNJ-90301900 along with standard treatments.
  • The study is open-label, meaning both doctors and participants will know the treatment being given.
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Study details
    Squamous Cell Carcinoma of Head and Neck

NCT07219212

Johnson & Johnson Enterprise Innovation Inc.

25 April 2026

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