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A Study to Assess Adverse Events and Effectiveness of IntraVenous Infusions of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Study on safety and effects of ABBV-CLS-628 for ADPKD patients.

Recruiting
18-55 years
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

Study on Autosomal Dominant Polycystic Kidney Disease (ADPKD): This research is to check the safety and how well a new medicine, ABBV-CLS-628, works for people with ADPKD. ADPKD is a genetic disease causing cysts in kidneys.

In this study, participants get ABBV-CLS-628 or a placebo (fake treatment) through an IV, which is a tube that goes into a vein, every four weeks for 92 weeks. A placebo is used to compare if the medicine really works. Each person has a 1 in 4 chance of getting the placebo. There will be about 240 adults in the study from around the world.

Participants will visit the hospital or clinic often for check-ups, blood tests, and to answer questions about how they feel. This study might require more effort than usual health care.

  • Timeline: IV treatment every 4 weeks for 92 weeks, followed by 15 weeks of follow-up.
  • Participants: 240 adults worldwide, divided into 4 groups.
  • Commitment: Frequent clinic visits and assessments.
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Study details
    Autosomal Dominant Polycystic Kidney Disease

NCT06902558

AbbVie

25 April 2026

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