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CSP #2026 - Beta Blocker Dialyzability on Cardiovascular Outcomes

Join a study on beta blockers' effects on heart health during dialysis.

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is about comparing two medicines, called beta blockers, to see which one is better for people on hemodialysis, a treatment for kidney disease where a machine cleans the blood. The two beta blockers are **metoprolol succinate**, which is removed by dialysis and targets a specific heart receptor (beta-1), and **carvedilol**, which stays in the body during dialysis and affects more than one receptor (beta and alpha). The goal is to find out which medicine helps people live longer and have fewer heart problems.

To be part of the study, you must be on hemodialysis and take one of the beta blockers from the Veterans Affairs (VA) pharmacy. You can't join if you have problems making decisions, allergies to the medicines, or if your doctor doesn't agree with the medicine change.

  • The study focuses on improving heart health in dialysis patients.
  • It's important to know if the medicine is removed by dialysis or not.
  • Doctors and patients must agree to the medicine changes.
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Study details
    End-Stage Kidney Disease
    End-Stage Renal Disease

NCT05931276

VA Office of Research and Development

25 April 2026

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