**Study Summary:** This study tests a new drug called **Rina-S** for people with advanced solid tumors. Solid tumors are masses of cancer cells. This study is for tumors that can't be removed by surgery (called *unresectable*) or have spread to other parts of the body (*metastatic*). **Rina-S** is a special type of medicine that helps target cancer cells. The study will check how safe Rina-S is and look at any side effects. The study includes different parts that focus on various types of cancer like ovarian, endometrial, breast, lung, and mesothelioma. *Participants* will keep receiving the study drug until the cancer gets worse, there are bad side effects, or if something else happens like the participant decides to stop. **Key Points:** - **Study Duration:** Participants will receive the treatment until disease progression, side effects, or other conditions are met. - **Visits and Treatment:** Multiple visits for treatments and monitoring will be needed. - **Risks:** Potential side effects from the new drug and long-term study commitment. *Participants must meet certain conditions to join, like having measurable disease per specific criteria.*