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Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

Join our study on Rina-S for advanced tumors.

Recruiting
18 years and older
All
Phase 1/2
Study Overview: This study is testing a drug called Rina-S for people with certain types of advanced cancer that have either spread in the body or can’t be removed by surgery. Rina-S is a special kind of medicine that targets cancer cells. The study aims to see if it's safe and how well it works. Key Points: - **Participation Length:** Treatment continues until the cancer worsens, side effects are too severe, or other specific reasons occur. - **Eligibility:** Includes people with specific types of ovarian, endometrial, breast, lung, or other cancers that are hard to treat. - **Study Parts:** Involves different groups focusing on specific cancer types and treatment responses. Details: Participants will receive Rina-S until the cancer progresses, side effects become unacceptable, or they choose to stop. The study will examine how well the drug works against different cancer stages and what side effects might occur. Participants must have tried other treatments and have measurable cancer. Some people with lung disease or who’ve used similar drugs before may not be eligible. Note: Always discuss with your doctor to understand the risks and benefits before joining.
Study details
    High Grade Epithelial Ovarian Cancer
    High Grade Serous Ovarian Cancer
    Primary Peritoneal Carcinoma
    Fallopian Tube Cancer
    Endometrial Cancer
    Non-small Cell Lung Cancer
    Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer (NSCLC)
    Mesothelioma
    Breast Adenocarcinoma
    Triple Negative Breast Cancer
    Hormone Receptor-positive/Her2 Negative Breast Cancer
    Platinum-resistant Ovarian Cancer (PROC)
    Platinum Sensitive Ovarian Cancer (PSOC)
    Primary Refractory Ovarian Cancer
    Uterine Cancer

NCT05579366

Genmab

12 September 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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