This study is for people with HIV-1 who haven't used HIV medicines before. HIV-1 is a virus that affects the immune system, making it hard for the body to fight off infections. The usual treatment for HIV-1 involves taking a lot of medicines every day. In this study, researchers are testing a new treatment that combines two medicines, islatravir and ulonivirine, into one pill that you take once a week. They want to see if this new treatment works as well as the usual treatment. Researchers also want to make sure it is safe and that people can handle it without too many side effects.

• The study lasts for a certain time, but you will only need to take one pill a week.
• You will have regular check-ups to see how the treatment is working and if it's safe.
• You cannot join if you have other infections like hepatitis or if you've had cancer recently.