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Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

Docetaxel with androgen blockers for prostate cancer with low PSA response.

Recruiting
18 years and older
Male
Phase 3

This study is trying to find out if adding a drug called Docetaxel to the usual treatment for prostate cancer helps stop the cancer from growing or spreading. Prostate cancer is a disease where cells in the prostate (a part of the male reproductive system) grow uncontrollably. The usual treatment is a hormone treatment called Androgen Deprivation Therapy (ADT) and an Androgen-Receptor Pathway Inhibitor (ARPI).

In this study, they are testing if adding Docetaxel, a chemotherapy drug, makes the treatment more effective for patients whose prostate-specific antigen (PSA) levels aren’t responding well. PSA is a protein made by the prostate, and high levels can be a sign of cancer.

  • The study lasts between 6 to 12 months after starting ADT and ARPI therapy.
  • Participants must be able to take Docetaxel and get regular check-ups.
  • Patients will need to sign consent forms and use safe contraception if they can have children.
Study details
    Prostate Cancer (Adenocarcinoma)

NCT06592924

Canadian Cancer Trials Group

14 March 2026

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