This study is looking at how safe and effective a medicine called RE104 is for people with Adjustment Disorder (AjD) because of illnesses like cancer, ALS, MS, PD, or IPF. Adjustment Disorder means feeling very sad or anxious due to a big change or illness. The study gives a one-time shot of RE104 and compares its effects to a look-alike treatment called an active-placebo.

Eligibility: To join, you need to have been feeling sad or anxious for at least 4 weeks because of one of the mentioned illnesses. You should be able to move around and care for yourself, think clearly, and have been on steady medicine or therapy, or agree to wait until the study ends. You also shouldn’t be pregnant or planning to have a baby soon.

Key Points:

• This study involves a one-time treatment.
• Participants should be stable on their current treatment.
• Refrain from using certain medications during the study.