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Celecoxib, Durvalumab and Tremelimumab for the Treatment of Patients With Advanced or Metastatic Liver Cancer

Exploring new liver cancer treatments with Celecoxib, Durvalumab, and Tremelimumab.

Recruiting
18 years and older
All
Phase 2

This study is exploring a new treatment for liver cancer that has spread, using three medicines: celecoxib, durvalumab, and tremelimumab. Celecoxib is a pain reliever that may stop cancer cells from growing. Durvalumab and tremelimumab help the body's immune system fight cancer. This study tests how well these drugs work together to treat liver cancer.

Key Points:

  • Study Duration: Every 28 days, with each cycle repeating unless disease worsens or side effects are too strong. Follow-ups last up to 2 years.
  • Tests Needed: Blood tests, CT or MRI scans, and possibly a tissue biopsy may be required.
  • Eligibility: Must be 18+, have a certain health status, and not have certain health conditions or be on conflicting medications.

After treatment, patients are monitored for side effects and the treatment's effectiveness. Participation requires visits for tests and treatments, and agreement to the study's rules. The study aims to see if this combination is safe and works better than existing treatments.

Study details
    Advanced Hepatocellular Carcinoma
    Metastatic Hepatocellular Carcinoma
    Stage III Hepatocellular Carcinoma AJCC v8
    Stage IV Hepatocellular Carcinoma AJCC v8

NCT07174570

Emory University

7 March 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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