**Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D) Study Summary** CAPTAIN-T2D is a research study for people with type 2 diabetes (T2D) and high cortisol levels. Cortisol is a hormone that can affect blood sugar. The study has two parts: Screening and Treatment. **Screening** lasts about 5 to 9 weeks. During this time, doctors check if you are eligible by doing tests like the dexamethasone suppression test, which measures how your body responds to the medicine dexamethasone. If eligible, you move to the **Treatment** phase, which lasts 24 weeks. In this phase, you receive either the study drug, clofutriben, or a placebo (a substance with no active drug) to see how it affects blood sugar control. **Key Points:** - **Study Duration**: Screening (5-9 weeks) + Treatment (24 weeks) - **Participation**: Involves visits for tests and taking study medication - **Eligibility**: Must have T2D, stable treatment, specific cortisol levels, and no recent diabetes onset This study aims to find the best dose of clofutriben for managing T2D and high cortisol levels. Participants must be at least 18 years old and meet specific health criteria.