Summary: This study is for people with colorectal cancer that can't be removed by surgery or has spread to other parts of the body. The study will compare two treatments: one using a new drug called pumitamig with chemotherapy, and the other using bevacizumab with chemotherapy. Colorectal cancer is cancer of the colon or rectum. Metastatic means the cancer has spread. Bevacizumab is a drug that stops the growth of blood vessels that feed tumors.

• The study is for people who haven't had treatment for their cancer yet.
• Participants will need to have tests and follow visits as per the study schedule.
• Potential risks and benefits of treatment will be closely monitored.

Note: You cannot join if you have had certain treatments before, have other recent cancers, or serious heart problems.