This study is testing the Indigo™ Aspiration System, a medical tool, to see if it safely and effectively removes blood clots. These clots can block blood flow to your legs, a condition called lower extremity acute limb ischemia (LE ALI). To join, you must be at least 18 years old and have a confirmed blockage in a leg artery, not higher than the common iliac artery. The symptoms must have started within the last 14 days. You cannot join if you have a life expectancy of less than a year, if your clot is in certain areas like the aorta, or if you've had some types of leg amputations or surgeries recently. Pregnant individuals or those with certain medical conditions or allergies are also excluded.

• The study involves first-line treatment using the Indigo Aspiration System.
• Participation requires informed consent and a commitment to follow-up visits.
• Participants might need to stop other investigational drug or device studies.