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Phase 2 Study of Glofitamab Monotherapy & With Polatuzumab Vedotin, Pirtobrutinib, or Atezolizumab in Richter's Transformation

Testing Glofitamab with other drugs in Richter's Transformation trial.

Recruiting
18 years and older
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is exploring new ways to treat a specific type of cancer called Richter's Transformation (RT), which comes from Chronic Lymphocytic Leukemia (CLL). It will test a drug called Glofitamab alone or with other drugs. Glofitamab has been used for similar cancer types, but not specifically for RT. The study will last about 9 months, with follow-ups for up to 10 years.

Participants will have to visit clinics, have blood and urine tests, and undergo scans like PET or CT. The study will involve about 70 people. The study drugs are not yet FDA-approved for RT but are used for other cancers.

  • Participants will receive treatments for about 9 months and be monitored every 3-6 months for up to 10 years.
  • It involves several clinic visits, blood tests, and scans.
  • Eligibility depends on specific cancer stages and past treatments.

Before joining, consider the time commitment, possible side effects, and if the treatment has been tried in your specific condition. If you're interested, talk to your doctor about joining this study.

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Study details
    Chronic Lymphocytic Leukemia
    Richter's Transformation

NCT06043674

Christine Ryan

7 March 2026

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