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A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Multiple Myeloma Receiving Etentamig (ABBV-383) as an Intravenous (IV) Infusion Alone or in Combination With Oral, IV, Subcutaneous Daratumumab; Lenalidomide; Dexamethasone; Carfilzomib

Clinical trial studying multiple myeloma treatment effects and safety.

Recruiting
18 years and older
All
Phase 1/2
  • Simplified description (AI rewritten)
  • Technical description (Original)

Multiple Myeloma (MM) is a type of cancer that affects plasma cells in the blood. It can cause bone pain, fractures, and even kidney problems. This study looks at a new drug called Etentamig to see if it can help treat MM. Etentamig is being tested alone and with other drugs like daratumumab, lenalidomide, carfilzomib, and dexamethasone.

The study is divided into 4 parts and involves trying different drug doses to find what works best. Around 440 adults with MM will participate at about 50 locations worldwide. Participants will receive the drug through an intravenous (IV) infusion, which means it is given directly into a vein. The study will last approximately 130 months (about 10 years and 10 months). Participants will need to visit a clinic or hospital regularly for check-ups, blood tests, and to monitor for any side effects.

  • Study lasts around 130 months.
  • Participants will have regular hospital or clinic visits.
  • It might be more demanding than regular treatment.
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Study details
    Multiple Myeloma

NCT06892522

AbbVie

7 March 2026

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