This study aims to develop a test to detect early gynecologic cancers, like endometrial, ovarian, and cervical cancer, using special markers in DNA called **Methylated DNA Markers (MDMs)**. These markers, along with a virus test for **Human Papillomavirus (HPV)**, will be found in vaginal fluid and blood. Early detection can improve chances of cure and reduce the need for tough treatments like surgery or chemotherapy. **Key Points:** - The study involves different groups of women, based on age and medical history. - Participants may need to provide samples of vaginal fluid or blood for analysis. - Some women will undergo surgical procedures as part of the study. To join, women must fit certain criteria, like age or symptoms, and cannot have had recent treatments or surgeries for cancer. If you are a woman experiencing abnormal bleeding or have risks for these cancers, this study could be an opportunity to help research and potentially improve detection methods.