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Safety Study of MELK Inhibitor to Treat Patients With Advanced Breast Cancer and Triple Negative Breast Cancer

Testing a new treatment for advanced and triple-negative breast cancer.

Recruiting
18 years and older
All
Phase 1
Study Overview: This study aims to find the highest safe dose of a drug called OTS167 for patients with advanced breast cancer, including Triple Negative Breast Cancer (TNBC). OTS167 is taken as a capsule by mouth. The study involves patients whose cancer has returned or does not respond to standard treatments. Eligibility: Women aged 18 or older with advanced or metastatic breast cancer can participate. Participants must have cancer that cannot be treated with surgery and must have already tried standard treatments. Patients must be able to provide informed consent and agree to use effective birth control during the study. Exclusions: Pregnant or breastfeeding women, those with uncontrolled brain metastases, or certain blood and heart conditions cannot participate. Patients with other serious infections or those who recently had major surgery or specific treatments are also excluded.
  • This study involves taking an oral medication and requires regular visits for monitoring.
  • Participants must have a life expectancy of at least 3 months and stable health conditions.
  • There may be risks, including potential side effects from the study drug.
Study details
    Relapsed/Refractory Locally Advanced or Metastatic Breast Cancer and Triple Negative Breast Cancer

NCT02926690

OncoTherapy Science, Inc.

7 March 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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