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Venetoclax and Obinutuzumab Followed by Epcoritamab for the Treatment of Untreated Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma, LonGEVity Trial

Testing new treatments for certain types of leukemia and lymphoma.

Recruiting
18 years and older
All
Phase 2

This study aims to test a treatment for people with certain types of blood cancer: Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL). The treatment involves three drugs: Venetoclax, Obinutuzumab, and Epcoritamab. Venetoclax stops cancer cells from growing by blocking a protein they need. Obinutuzumab and Epcoritamab are special proteins called antibodies that help the immune system attack cancer cells. This study is for patients who have not yet received treatment for CLL or SLL.

  • Participants will receive the treatment for up to 12 cycles, each lasting 28 days.
  • Afterwards, regular follow-up visits will continue for up to 5 years to check patient health.
  • Participants must be 18 or older and meet specific health requirements to join.

Throughout the study, patients will have blood tests and imaging scans like CT or MRI. They may also have bone marrow tests. This study aims to see if adding Epcoritamab can improve treatment results. Joining involves regular visits to the clinic, but it offers a chance to help find better treatments for these cancers. Always discuss with your doctor before joining any study.

Study details
    Chronic Lymphocytic Leukemia
    Small Lymphocytic Lymphoma

NCT07218510

City of Hope Medical Center

7 March 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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