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Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

Exploring DISC-0974 for those with Myelofibrosis or Myelodysplastic Syndrome.

Recruiting
18 years and older
All
Phase 1/2

This study is looking at a new drug, DISC-0974, to help people with two blood problems: myelofibrosis and myelodysplastic syndrome, both of which can cause anemia (low red blood cells). The study aims to see if the drug is safe and effective in treating anemia caused by these conditions.

Participants must be 18 or older, have anemia, and meet specific health criteria. For example, they should not have had certain treatments recently, like blood transfusions or specific medications, and should not have other health issues that could interfere with the study. Women of childbearing age must use effective birth control.

  • The study includes several visits over time, but exact details on how many are not provided here.
  • Participants must stop certain medications 28 days before starting the study.
  • There might be risks involved, but details are not specified here.

Anyone interested should talk to their doctor to see if they qualify and to understand potential benefits and risks.

Study details
    Myelofibrosis; Anemia
    Anemia
    Myelofibrosis
    Myelofibrosis Due to and Following Polycythemia Vera
    Primary Myelofibrosis
    Post-essential Thrombocythemia Myelofibrosis
    Myelodysplastic Syndromes

NCT05320198

Disc Medicine, Inc

7 March 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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