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Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

Testing Daraxonrasib in patients with RAS-mutated lung cancer.

Recruiting
18 years and older
All
Phase 3

This research is testing a new drug called **daraxonrasib** against a standard chemotherapy drug, **docetaxel**, for adults with a type of lung cancer called NSCLC (Non-Small Cell Lung Cancer). NSCLC is a type of cancer that affects the lungs and has certain genetic changes called **RAS mutations**. The study will see if daraxonrasib helps patients live longer or slows down the cancer compared to docetaxel.

Participants will be randomly assigned to one of two groups: one group will receive daraxonrasib, and the other will receive docetaxel. This study is open-label, meaning everyone involved knows which treatment the participants are getting.

  • The study is global and involves patients previously treated for NSCLC.
  • Participants need to be at least 18 years old and able to take pills.
  • People with untreated brain cancer, serious health issues, or who are pregnant can't participate.

Choosing to join this study means regular visits to the doctor, but it might help find better treatments for lung cancer in the future.

Study details
    NSCLC (Non-small Cell Lung Cancer)
    Non-Small Cell Lung Cancer
    NSCLC
    NSCLC (Non-small Cell Lung Carcinoma)
    NSCLC (Advanced Non-small Cell Lung Cancer)

NCT06881784

Revolution Medicines, Inc.

12 September 2026

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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