Researchers are studying a new drug called ASP5834 to help people with certain types of cancer called solid tumors. Genes are like instructions in our body, and sometimes they change, which can cause cancer. One of these changes happens in a gene called KRAS. This study involves adults with tumors that can't be removed by surgery and have spread to other parts of their body.

In the study, people might get ASP5834 alone or with another drug for colorectal cancer called panitumumab. The study will help find the right dose and check for any health problems from ASP5834. It's the first time this drug is being tested in humans.

• The study can last about 1 year with multiple clinic visits for health checks and scans.
• Participants with specific health issues like uncontrolled heart problems cannot join.
• ASP5834 is given through a vein in cycles of either 21 or 28 days.

The study is open-label, meaning everyone knows what treatment they are getting. If you join, you'll have regular health checks and possibly tumor samples taken. It's important to know that participation is voluntary, and you can stop at any time if you want to.